Drug interactions
Capivasertib + Chloramphenicol
Severity: Moderate
Capivasertib and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib is metabolized by CYP3A4, and inhibitors can raise its exposure, increasing hyperglycemia, diarrhea and rash. Chloramphenicol may produce this effect.
What this interaction means in plain words
Capivasertib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of capivasertib.
What to do
Prefer a different antibiotic. If necessary, reduce the capivasertib dose per labeling and monitor blood glucose and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Chloramphenicol?
MediHelp rates the interaction as moderate. Capivasertib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capivasertib is metabolized by CYP3A4, and inhibitors can raise its exposure, increasing hyperglycemia, diarrhea and rash. Chloramphenicol may produce this effect.
How serious is the interaction between Capivasertib and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a different antibiotic. If necessary, reduce the capivasertib dose per labeling and monitor blood glucose and adverse effects.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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