Drug interactions
Capivasertib + Imatinib
Severity: Moderate
Capivasertib and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib is metabolized by CYP3A4 and UGT2B7, and imatinib is a moderate CYP3A4 inhibitor that may increase capivasertib exposure. This could worsen hyperglycemia, diarrhea and rash.
What this interaction means in plain words
Capivasertib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4 and reduces capivasertib clearance.
What to do
Monitor glucose and gastrointestinal and skin toxicity, and consider reducing the capivasertib dose in line with product labeling for moderate CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Imatinib?
MediHelp rates the interaction as moderate. Capivasertib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capivasertib is metabolized by CYP3A4 and UGT2B7, and imatinib is a moderate CYP3A4 inhibitor that may increase capivasertib exposure. This could worsen hyperglycemia, diarrhea and rash.
How serious is the interaction between Capivasertib and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and gastrointestinal and skin toxicity, and consider reducing the capivasertib dose in line with product labeling for moderate CYP3A4 inhibitors.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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