Drug interactions
Capivasertib + Lapatinib
Severity: Moderate
Capivasertib and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib may increase capivasertib exposure by inhibiting its CYP3A4-mediated clearance. This could worsen hyperglycemia, diarrhea, rash and other adverse effects of capivasertib.
What this interaction means in plain words
Capivasertib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of capivasertib by lapatinib.
What to do
Consider reducing the capivasertib dose as recommended in labeling for moderate CYP3A inhibitors. Monitor blood glucose, skin reactions and gastrointestinal tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Capivasertib and Lapatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Lapatinib?
MediHelp rates the interaction as moderate. Capivasertib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib may increase capivasertib exposure by inhibiting its CYP3A4-mediated clearance. This could worsen hyperglycemia, diarrhea, rash and other adverse effects of capivasertib.
How serious is the interaction between Capivasertib and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the capivasertib dose as recommended in labeling for moderate CYP3A inhibitors. Monitor blood glucose, skin reactions and gastrointestinal tolerance.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
