Drug interactions
Capivasertib + Ritonavir
Severity: Major
Capivasertib and Ritonavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 and raises capivasertib exposure. This may increase adverse effects such as hyperglycemia, diarrhea and rash.
What this interaction means in plain words
Capivasertib and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capivasertib belongs to Oncology; Ritonavir belongs to Anti Virals.
Why it happens
Strong CYP3A4 inhibition reduces capivasertib clearance.
What to do
Avoid if possible; otherwise reduce capivasertib to 320 mg twice daily and monitor glucose and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Capivasertib
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Capivasertib with Ritonavir?
MediHelp rates the interaction as major. Capivasertib and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir strongly inhibits CYP3A4 and raises capivasertib exposure. This may increase adverse effects such as hyperglycemia, diarrhea and rash.
How serious is the interaction between Capivasertib and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce capivasertib to 320 mg twice daily and monitor glucose and tolerability.
What other medicines interact with Capivasertib?
MediHelp also lists interactions of Capivasertib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Capivasertib page.
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