Drug interactions
Capivasertib + Sertraline
Severity: Minor
Capivasertib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib is metabolized by CYP3A4, and sertraline is only a weak inhibitor of this enzyme. A meaningful increase in capivasertib exposure is therefore unlikely.
What this interaction means in plain words
Capivasertib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Capivasertib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated capivasertib metabolism by sertraline.
What to do
No dose adjustment is usually required. Monitor for capivasertib toxicity such as hyperglycemia, diarrhea and rash.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Sertraline?
MediHelp rates the interaction as minor. Capivasertib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Capivasertib is metabolized by CYP3A4, and sertraline is only a weak inhibitor of this enzyme. A meaningful increase in capivasertib exposure is therefore unlikely.
How serious is the interaction between Capivasertib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Monitor for capivasertib toxicity such as hyperglycemia, diarrhea and rash.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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