Drug interactions
Capivasertib + Verapamil
Severity: Moderate
Capivasertib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil increases capivasertib exposure by inhibiting CYP3A4. This may worsen hyperglycemia, diarrhea, rash and other toxicities.
What this interaction means in plain words
Capivasertib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Moderate CYP3A inhibition decreases capivasertib clearance.
What to do
Reduce the capivasertib dose per labeling when combined with a moderate CYP3A inhibitor, and monitor blood glucose and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Capivasertib and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Verapamil?
MediHelp rates the interaction as moderate. Capivasertib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil increases capivasertib exposure by inhibiting CYP3A4. This may worsen hyperglycemia, diarrhea, rash and other toxicities.
How serious is the interaction between Capivasertib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the capivasertib dose per labeling when combined with a moderate CYP3A inhibitor, and monitor blood glucose and tolerability.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
