Drug interactions
Caplacizumab + Fondaparinux
Severity: Major
Caplacizumab and Fondaparinux: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caplacizumab blocks von Willebrand factor-platelet binding and impairs primary hemostasis. With fondaparinux's anticoagulant effect, the risk of bleeding is increased.
What this interaction means in plain words
Caplacizumab and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Caplacizumab belongs to Cardiovascular; Fondaparinux belongs to Cardiovascular.
Why it happens
Additive impairment of hemostasis via von Willebrand factor/platelet inhibition and factor Xa inhibition.
What to do
Monitor closely for bleeding and consider withholding or holding one agent if bleeding occurs. Follow caplacizumab labeling on interrupting it before procedures.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Caplacizumab
Frequently asked questions
Can I take Caplacizumab with Fondaparinux?
MediHelp rates the interaction as major. Caplacizumab and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-platelet binding and impairs primary hemostasis. With fondaparinux's anticoagulant effect, the risk of bleeding is increased.
How serious is the interaction between Caplacizumab and Fondaparinux?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding and consider withholding or holding one agent if bleeding occurs. Follow caplacizumab labeling on interrupting it before procedures.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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