Drug interactions
Caplacizumab + Rivaroxaban
Severity: Major
Caplacizumab and Rivaroxaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion and impairs primary haemostasis. Added to a factor Xa inhibitor, the risk of serious spontaneous or procedural bleeding rises markedly.
What this interaction means in plain words
Caplacizumab and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Caplacizumab belongs to Cardiovascular; Rivaroxaban belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect: antiplatelet-like von Willebrand factor blockade plus anticoagulation through factor Xa inhibition.
What to do
Avoid combining where possible; if anticoagulation is essential, monitor closely for bleeding and consider temporarily holding rivaroxaban. Hold caplacizumab before invasive procedures per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Caplacizumab
Frequently asked questions
Can I take Caplacizumab with Rivaroxaban?
MediHelp rates the interaction as major. Caplacizumab and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion and impairs primary haemostasis. Added to a factor Xa inhibitor, the risk of serious spontaneous or procedural bleeding rises markedly.
How serious is the interaction between Caplacizumab and Rivaroxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if anticoagulation is essential, monitor closely for bleeding and consider temporarily holding rivaroxaban. Hold caplacizumab before invasive procedures per labeling.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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