Drug interactions
Captopril + Clofarabine
Severity: Moderate
Captopril and Clofarabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clofarabine can cause hypotension as part of systemic inflammatory response or capillary leak syndrome. Antihypertensives such as captopril may worsen this, and clofarabine is also nephrotoxic, which is relevant to ACE inhibitor use.
What this interaction means in plain words
Captopril and Clofarabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Clofarabine belongs to Oncology.
Why it happens
Additive hypotension and potential renal effects; clofarabine-related hemodynamic instability combined with ACE inhibition.
What to do
Consider holding captopril during clofarabine administration, and monitor blood pressure and renal function closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Clofarabine
- Clofarabine + Siponimod Major
- Clofarabine + Tofacitinib Major
- Amlodipine-benazepril + Clofarabine Moderate
- Benazepril + Clofarabine Moderate
- Captopril-hydrochlorothiazide + Clofarabine Moderate
- Cimetidine + Clofarabine Moderate
Frequently asked questions
Can I take Captopril with Clofarabine?
MediHelp rates the interaction as moderate. Captopril and Clofarabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clofarabine can cause hypotension as part of systemic inflammatory response or capillary leak syndrome. Antihypertensives such as captopril may worsen this, and clofarabine is also nephrotoxic, which is relevant to ACE inhibitor use.
How serious is the interaction between Captopril and Clofarabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding captopril during clofarabine administration, and monitor blood pressure and renal function closely.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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