Drug interactions
Captopril-hydrochlorothiazide + Clofarabine
Severity: Moderate
Captopril-hydrochlorothiazide and Clofarabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clofarabine can cause hypotension as part of a systemic inflammatory or capillary leak reaction, and antihypertensives may add to this. Clofarabine is also nephrotoxic, and the diuretic and ACE inhibitor may worsen renal risk with volume depletion.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Clofarabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Clofarabine belongs to Oncology.
Why it happens
Additive hypotensive effects and potential additive renal hemodynamic stress.
What to do
Consider holding the antihypertensive during clofarabine infusion and monitor blood pressure, hydration and renal function closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Clofarabine
- Clofarabine + Siponimod Major
- Clofarabine + Tofacitinib Major
- Amlodipine-benazepril + Clofarabine Moderate
- Benazepril + Clofarabine Moderate
- Captopril + Clofarabine Moderate
- Cimetidine + Clofarabine Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Clofarabine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Clofarabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clofarabine can cause hypotension as part of a systemic inflammatory or capillary leak reaction, and antihypertensives may add to this. Clofarabine is also nephrotoxic, and the diuretic and ACE inhibitor may worsen renal risk with volume depletion.
How serious is the interaction between Captopril-hydrochlorothiazide and Clofarabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding the antihypertensive during clofarabine infusion and monitor blood pressure, hydration and renal function closely.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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