Drug interactions
Cimetidine + Clofarabine
Severity: Moderate
Cimetidine and Clofarabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clofarabine is renally eliminated through active tubular secretion, and cimetidine inhibits organic cation transporters. Cimetidine may raise clofarabine exposure and its toxicity, though human data are limited.
What this interaction means in plain words
Cimetidine and Clofarabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Clofarabine belongs to Oncology.
Why it happens
Cimetidine inhibits renal tubular transporters (OCT/OAT) involved in clofarabine excretion.
What to do
Monitor for hematologic, hepatic and renal toxicity, or use an alternative acid suppressant such as a proton pump inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clofarabine
- Clofarabine + Siponimod Major
- Clofarabine + Tofacitinib Major
- Amlodipine-benazepril + Clofarabine Moderate
- Benazepril + Clofarabine Moderate
- Captopril-hydrochlorothiazide + Clofarabine Moderate
- Captopril + Clofarabine Moderate
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Clofarabine?
MediHelp rates the interaction as moderate. Cimetidine and Clofarabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clofarabine is renally eliminated through active tubular secretion, and cimetidine inhibits organic cation transporters. Cimetidine may raise clofarabine exposure and its toxicity, though human data are limited.
How serious is the interaction between Cimetidine and Clofarabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hematologic, hepatic and renal toxicity, or use an alternative acid suppressant such as a proton pump inhibitor.
What other medicines interact with Clofarabine?
MediHelp also lists interactions of Clofarabine with, for example, Siponimod, Tofacitinib, Amlodipine-benazepril. The full list is on the Clofarabine page.
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