Drug interactions
Amlodipine-benazepril + Clofarabine
Severity: Moderate
Amlodipine-benazepril and Clofarabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clofarabine can cause hypotension, particularly with capillary leak or systemic inflammatory responses. Concurrent antihypertensives may worsen this.
What this interaction means in plain words
Amlodipine-benazepril and Clofarabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Clofarabine belongs to Oncology.
Why it happens
Additive hypotensive effects between clofarabine toxicity and antihypertensives.
What to do
Monitor blood pressure during clofarabine infusions. Consider withholding antihypertensives temporarily if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Clofarabine
- Clofarabine + Siponimod Major
- Clofarabine + Tofacitinib Major
- Benazepril + Clofarabine Moderate
- Captopril-hydrochlorothiazide + Clofarabine Moderate
- Captopril + Clofarabine Moderate
- Cimetidine + Clofarabine Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Clofarabine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Clofarabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clofarabine can cause hypotension, particularly with capillary leak or systemic inflammatory responses. Concurrent antihypertensives may worsen this.
How serious is the interaction between Amlodipine-benazepril and Clofarabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during clofarabine infusions. Consider withholding antihypertensives temporarily if hypotension develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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