Drug interactions
Clofarabine + Tofacitinib
Severity: Major
Clofarabine and Tofacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune function, and clofarabine also causes marked myelosuppression. Together they raise the risk of serious and opportunistic infections.
What this interaction means in plain words
Clofarabine and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clofarabine belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression and myelosuppression through JAK inhibition and nucleoside antimetabolite cytotoxicity.
What to do
Avoid concurrent use where possible and interrupt tofacitinib during clofarabine cycles. Monitor blood counts and watch for signs of infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clofarabine and Tofacitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Clofarabine
- Clofarabine + Siponimod Major
- Amlodipine-benazepril + Clofarabine Moderate
- Benazepril + Clofarabine Moderate
- Captopril-hydrochlorothiazide + Clofarabine Moderate
- Captopril + Clofarabine Moderate
- Cimetidine + Clofarabine Moderate
Frequently asked questions
Can I take Clofarabine with Tofacitinib?
MediHelp rates the interaction as major. Clofarabine and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function, and clofarabine also causes marked myelosuppression. Together they raise the risk of serious and opportunistic infections.
How serious is the interaction between Clofarabine and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and interrupt tofacitinib during clofarabine cycles. Monitor blood counts and watch for signs of infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
