Drug interactions
Captopril + Digoxin
Severity: Moderate
Captopril and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Captopril has been reported to raise digoxin concentrations modestly in some patients, possibly through reduced renal clearance. Because both drugs are used in heart failure and renal function may change, digoxin toxicity could occur.
What this interaction means in plain words
Captopril and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Possible reduction in renal digoxin clearance; mechanism not firmly established.
What to do
Monitor digoxin levels, renal function and potassium when starting captopril. Reduce the digoxin dose if concentrations are elevated or toxicity signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Captopril with Digoxin?
MediHelp rates the interaction as moderate. Captopril and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Captopril has been reported to raise digoxin concentrations modestly in some patients, possibly through reduced renal clearance. Because both drugs are used in heart failure and renal function may change, digoxin toxicity could occur.
How serious is the interaction between Captopril and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels, renal function and potassium when starting captopril. Reduce the digoxin dose if concentrations are elevated or toxicity signs appear.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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