Drug interactions
Captopril + Everolimus
Severity: Major
Captopril and Everolimus: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
mTOR inhibitors such as everolimus are associated with angioedema, and the risk is higher when combined with an ACE inhibitor. Swelling of the face, lips, tongue or airway can be serious.
What this interaction means in plain words
Captopril and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Captopril belongs to Cardiovascular; Everolimus belongs to Oncology.
Why it happens
Both drugs impair bradykinin degradation or increase bradykinin-mediated effects, with mTOR inhibition reducing DPP-IV activity.
What to do
Counsel patients to seek urgent care for swelling of the face, lips or throat. Stop the ACE inhibitor and use an alternative antihypertensive if angioedema occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Captopril with Everolimus?
MediHelp rates the interaction as major. Captopril and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. mTOR inhibitors such as everolimus are associated with angioedema, and the risk is higher when combined with an ACE inhibitor. Swelling of the face, lips, tongue or airway can be serious.
How serious is the interaction between Captopril and Everolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to seek urgent care for swelling of the face, lips or throat. Stop the ACE inhibitor and use an alternative antihypertensive if angioedema occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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