Drug interactions
Captopril + Finerenone
Severity: Major
Captopril and Finerenone: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ACE inhibitors and finerenone, a mineralocorticoid receptor antagonist, raise serum potassium. Used together, hyperkalemia risk increases, especially in patients with chronic kidney disease or diabetes.
What this interaction means in plain words
Captopril and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Captopril belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Additive hyperkalemia from reduced aldosterone production (ACE inhibition) and mineralocorticoid receptor blockade.
What to do
Check serum potassium and renal function before starting finerenone and regularly after, adjusting or interrupting finerenone per its labeled potassium thresholds.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Captopril with Finerenone?
MediHelp rates the interaction as major. Captopril and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both ACE inhibitors and finerenone, a mineralocorticoid receptor antagonist, raise serum potassium. Used together, hyperkalemia risk increases, especially in patients with chronic kidney disease or diabetes.
How serious is the interaction between Captopril and Finerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function before starting finerenone and regularly after, adjusting or interrupting finerenone per its labeled potassium thresholds.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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