Drug interactions
Captopril + Glipizide
Severity: Moderate
Captopril and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and enhance the glucose-lowering effect of sulfonylureas. Hypoglycemia may occur, especially after starting captopril or in patients with renal impairment.
What this interaction means in plain words
Captopril and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Glipizide belongs to Endocrine.
Why it happens
ACE inhibition improves insulin sensitivity, adding to sulfonylurea-induced insulin secretion.
What to do
Monitor blood glucose when starting or adjusting captopril. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Glipizide
Frequently asked questions
Can I take Captopril with Glipizide?
MediHelp rates the interaction as moderate. Captopril and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and enhance the glucose-lowering effect of sulfonylureas. Hypoglycemia may occur, especially after starting captopril or in patients with renal impairment.
How serious is the interaction between Captopril and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting captopril. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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