Drug interactions
Captopril + Linagliptin
Severity: Moderate
Captopril and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DPP-4 inhibitors reduce breakdown of substance P and bradykinin, and combined with an ACE inhibitor this may raise the risk of angioedema. The absolute risk appears small but the reaction can involve the airway.
What this interaction means in plain words
Captopril and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Linagliptin belongs to Endocrine.
Why it happens
Reduced degradation of bradykinin and substance P through both ACE and DPP-4 inhibition.
What to do
Advise patients to report swelling of the lips, face or tongue immediately. Stop the offending drugs and treat if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Captopril with Linagliptin?
MediHelp rates the interaction as moderate. Captopril and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors reduce breakdown of substance P and bradykinin, and combined with an ACE inhibitor this may raise the risk of angioedema. The absolute risk appears small but the reaction can involve the airway.
How serious is the interaction between Captopril and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report swelling of the lips, face or tongue immediately. Stop the offending drugs and treat if angioedema occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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