Drug interactions
Captopril + Methamphetamine
Severity: Moderate
Captopril and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine raises blood pressure through sympathomimetic stimulation and can counteract the antihypertensive effect of captopril. Hypertensive control may be lost and cardiovascular risk increased.
What this interaction means in plain words
Captopril and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Methamphetamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between sympathomimetic pressor effects and ACE inhibitor vasodilation.
What to do
Monitor blood pressure closely and adjust antihypertensive therapy if needed. Consider whether the stimulant is appropriate in patients with uncontrolled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Captopril with Methamphetamine?
MediHelp rates the interaction as moderate. Captopril and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine raises blood pressure through sympathomimetic stimulation and can counteract the antihypertensive effect of captopril. Hypertensive control may be lost and cardiovascular risk increased.
How serious is the interaction between Captopril and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and adjust antihypertensive therapy if needed. Consider whether the stimulant is appropriate in patients with uncontrolled hypertension.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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