Drug interactions
Captopril + Pentoxifylline
Severity: Minor
Captopril and Pentoxifylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentoxifylline has vasodilating properties and has occasionally been associated with hypotension, which may add to the effect of captopril. The effect is usually mild.
What this interaction means in plain words
Captopril and Pentoxifylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Pentoxifylline belongs to Cardiovascular.
Why it happens
Additive vasodilatory and blood pressure lowering effects.
What to do
Monitor blood pressure after starting pentoxifylline and reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Pentoxifylline
- Amifostine + Pentoxifylline Moderate
- Fluoxetine + Pentoxifylline Moderate
- Fluvoxamine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Methoxsalen + Pentoxifylline Moderate
- Mexiletine + Pentoxifylline Moderate
Frequently asked questions
Can I take Captopril with Pentoxifylline?
MediHelp rates the interaction as minor. Captopril and Pentoxifylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentoxifylline has vasodilating properties and has occasionally been associated with hypotension, which may add to the effect of captopril. The effect is usually mild.
How serious is the interaction between Captopril and Pentoxifylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting pentoxifylline and reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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