Drug interactions
Captopril + Pregabalin
Severity: Moderate
Captopril and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with angioedema, and use together may add to the risk of swelling of the face, lips, tongue and airway. Angioedema can compromise breathing.
What this interaction means in plain words
Captopril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Pregabalin belongs to Central Nervous System.
Why it happens
Additive angioedema risk; ACE inhibitors raise bradykinin and pregabalin angioedema mechanism is not established.
What to do
Counsel patients to stop both drugs and seek urgent care for facial or throat swelling. Use extra vigilance in those with prior angioedema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Captopril with Pregabalin?
MediHelp rates the interaction as moderate. Captopril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with angioedema, and use together may add to the risk of swelling of the face, lips, tongue and airway. Angioedema can compromise breathing.
How serious is the interaction between Captopril and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to stop both drugs and seek urgent care for facial or throat swelling. Use extra vigilance in those with prior angioedema.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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