Drug interactions
Captopril + Sevoflurane
Severity: Moderate
Captopril and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as sevoflurane cause vasodilation and, together with ACE inhibitors, can result in significant hypotension during anesthesia. The risk is greater when captopril is taken shortly before surgery.
What this interaction means in plain words
Captopril and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive vasodilation from volatile anesthetic action and loss of angiotensin II vasoconstrictor tone.
What to do
Monitor blood pressure continuously and treat hypotension with fluids or vasopressors. Consider omitting captopril on the morning of surgery per local anesthetic protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Captopril with Sevoflurane?
MediHelp rates the interaction as moderate. Captopril and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as sevoflurane cause vasodilation and, together with ACE inhibitors, can result in significant hypotension during anesthesia. The risk is greater when captopril is taken shortly before surgery.
How serious is the interaction between Captopril and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously and treat hypotension with fluids or vasopressors. Consider omitting captopril on the morning of surgery per local anesthetic protocol.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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