Drug interactions
Captopril + Temsirolimus
Severity: Moderate
Captopril and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an ACE inhibitor with an mTOR inhibitor such as temsirolimus raises the likelihood of angioedema. Swelling of the face, lips, tongue or airway can develop and may be serious.
What this interaction means in plain words
Captopril and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Both drugs impair bradykinin breakdown (ACE inhibition and mTOR inhibition reducing dipeptidyl peptidase IV activity), so bradykinin accumulates and promotes angioedema.
What to do
Counsel the patient to report swelling of the face, lips, tongue or throat immediately. Stop the ACE inhibitor and switch to a different antihypertensive class if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Captopril with Temsirolimus?
MediHelp rates the interaction as moderate. Captopril and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an ACE inhibitor with an mTOR inhibitor such as temsirolimus raises the likelihood of angioedema. Swelling of the face, lips, tongue or airway can develop and may be serious.
How serious is the interaction between Captopril and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report swelling of the face, lips, tongue or throat immediately. Stop the ACE inhibitor and switch to a different antihypertensive class if angioedema occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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