Drug interactions
Captopril-hydrochlorothiazide + Carbidopa
Severity: Moderate
Captopril-hydrochlorothiazide and Carbidopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa is usually given with levodopa, and levodopa-containing regimens can cause orthostatic hypotension. This can add to the effect of captopril and hydrochlorothiazide, so symptomatic hypotension may occur especially at initiation.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Carbidopa belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotension, because levodopa (made more available by carbidopa) produces dopaminergic vasodilation and orthostatic blood pressure falls.
What to do
Monitor supine and standing blood pressure when levodopa-carbidopa is started or increased. Lower the antihypertensive dose if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Carbidopa?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa is usually given with levodopa, and levodopa-containing regimens can cause orthostatic hypotension. This can add to the effect of captopril and hydrochlorothiazide, so symptomatic hypotension may occur especially at initiation.
How serious is the interaction between Captopril-hydrochlorothiazide and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when levodopa-carbidopa is started or increased. Lower the antihypertensive dose if orthostatic symptoms occur.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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