Drug interactions
Captopril-hydrochlorothiazide + Cariprazine
Severity: Moderate
Captopril-hydrochlorothiazide and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine can cause orthostatic hypotension, which may add to the effects of captopril and hydrochlorothiazide. Falls and dizziness are a concern, especially in older adults.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Cariprazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from antipsychotic adrenergic blockade with ACE inhibition and diuresis.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating cariprazine. Reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Cariprazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Cariprazine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine can cause orthostatic hypotension, which may add to the effects of captopril and hydrochlorothiazide. Falls and dizziness are a concern, especially in older adults.
How serious is the interaction between Captopril-hydrochlorothiazide and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating cariprazine. Reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
