Drug interactions
Captopril-hydrochlorothiazide + Chlorothiazide
Severity: Moderate
Captopril-hydrochlorothiazide and Chlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide duplicates the thiazide component already in the combination product, so the diuretic effect, electrolyte loss and hypotension are increased. Volume depletion together with an ACE inhibitor raises the risk of acute kidney injury.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Why it happens
Therapeutic duplication of thiazide diuretics with additive natriuresis and volume depletion, combined with ACE inhibitor reduction of glomerular filtration pressure.
What to do
Avoid using two thiazides together unless a deliberate strategy is in place. If both are used, monitor blood pressure, serum sodium, potassium and creatinine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Chlorothiazide?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide duplicates the thiazide component already in the combination product, so the diuretic effect, electrolyte loss and hypotension are increased. Volume depletion together with an ACE inhibitor raises the risk of acute kidney injury.
How serious is the interaction between Captopril-hydrochlorothiazide and Chlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together unless a deliberate strategy is in place. If both are used, monitor blood pressure, serum sodium, potassium and creatinine.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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