Drug interactions
Captopril-hydrochlorothiazide + Ciprofloxacin
Severity: Moderate
Captopril-hydrochlorothiazide and Ciprofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin has a small QT-prolonging potential, and thiazide-induced hypokalemia or hypomagnesemia can increase the risk of torsades de pointes. The ACE inhibitor itself is not a significant contributor.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Ciprofloxacin belongs to Anti Bacterial.
Why it happens
Thiazide-induced electrolyte disturbances add to fluoroquinolone-related QT prolongation.
What to do
Check and correct potassium and magnesium before and during therapy, and consider an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Ciprofloxacin?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin has a small QT-prolonging potential, and thiazide-induced hypokalemia or hypomagnesemia can increase the risk of torsades de pointes. The ACE inhibitor itself is not a significant contributor.
How serious is the interaction between Captopril-hydrochlorothiazide and Ciprofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during therapy, and consider an ECG in patients with other QT risk factors.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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