Drug interactions
Captopril-hydrochlorothiazide + Diazoxide
Severity: Moderate
Captopril-hydrochlorothiazide and Diazoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazoxide is a vasodilator that can lower blood pressure and add to the effect of captopril and hydrochlorothiazide. Both diazoxide and thiazides also raise blood glucose, so hyperglycemia may be more pronounced.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Diazoxide belongs to Miscellaneous.
Why it happens
Additive hypotension through vasodilation, plus additive hyperglycemia from reduced insulin secretion by diazoxide and thiazide-related glucose intolerance.
What to do
Monitor blood pressure and blood glucose, particularly at initiation or dose changes. Adjust antidiabetic therapy or antihypertensives as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Diazoxide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Diazoxide?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazoxide is a vasodilator that can lower blood pressure and add to the effect of captopril and hydrochlorothiazide. Both diazoxide and thiazides also raise blood glucose, so hyperglycemia may be more pronounced.
How serious is the interaction between Captopril-hydrochlorothiazide and Diazoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and blood glucose, particularly at initiation or dose changes. Adjust antidiabetic therapy or antihypertensives as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
