Drug interactions
Captopril-hydrochlorothiazide + Folic acid
Severity: Minor
Captopril-hydrochlorothiazide and Folic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics have been reported to increase urinary folate loss, which could lower folate status over long-term use. The clinical impact is usually small in people with adequate dietary intake.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Folic acid belongs to Miscellaneous.
Why it happens
Possible increased renal excretion of folate with thiazide diuretics; the mechanism is not firmly established.
What to do
No routine action is needed; consider checking folate status in long-term users with poor intake or anemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Folic acid?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics have been reported to increase urinary folate loss, which could lower folate status over long-term use. The clinical impact is usually small in people with adequate dietary intake.
How serious is the interaction between Captopril-hydrochlorothiazide and Folic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; consider checking folate status in long-term users with poor intake or anemia.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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