Drug interactions
Captopril-hydrochlorothiazide + Glyburide
Severity: Moderate
Captopril-hydrochlorothiazide and Glyburide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and may increase the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The thiazide component can raise blood glucose and may oppose the sulfonylurea.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Glyburide belongs to Endocrine.
Why it happens
ACE inhibition improves insulin sensitivity, an additive pharmacodynamic effect, while thiazides reduce insulin sensitivity and glucose tolerance.
What to do
Monitor blood glucose, especially when starting or stopping the combination or in the first weeks of ACE inhibitor therapy. Adjust the glyburide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Glyburide?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and may increase the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The thiazide component can raise blood glucose and may oppose the sulfonylurea.
How serious is the interaction between Captopril-hydrochlorothiazide and Glyburide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, especially when starting or stopping the combination or in the first weeks of ACE inhibitor therapy. Adjust the glyburide dose as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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