Drug interactions
Captopril-hydrochlorothiazide + Isoproterenol
Severity: Moderate
Captopril-hydrochlorothiazide and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol and hydrochlorothiazide can each lower serum potassium, so combined use may cause hypokalemia and raise arrhythmia risk. This matters most with high-dose or prolonged isoproterenol use.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Beta-adrenergic stimulation drives potassium into cells while thiazides increase renal potassium loss, giving additive hypokalemia.
What to do
Monitor serum potassium and ECG when isoproterenol is given with a thiazide. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Isoproterenol?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol and hydrochlorothiazide can each lower serum potassium, so combined use may cause hypokalemia and raise arrhythmia risk. This matters most with high-dose or prolonged isoproterenol use.
How serious is the interaction between Captopril-hydrochlorothiazide and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG when isoproterenol is given with a thiazide. Replace potassium as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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