Drug interactions
Captopril-hydrochlorothiazide + L-methylfolate
Severity: Minor
Captopril-hydrochlorothiazide and L-methylfolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may increase urinary folate loss, which could marginally lower folate levels with prolonged use. The clinical relevance is generally minimal.
What this interaction means in plain words
Captopril-hydrochlorothiazide and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; L-methylfolate belongs to Miscellaneous.
Why it happens
Possible increased renal excretion of folate with thiazides; mechanism not firmly established.
What to do
No routine change is needed; monitor folate status in patients with poor intake or deficiency.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of L-methylfolate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with L-methylfolate?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics may increase urinary folate loss, which could marginally lower folate levels with prolonged use. The clinical relevance is generally minimal.
How serious is the interaction between Captopril-hydrochlorothiazide and L-methylfolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor folate status in patients with poor intake or deficiency.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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