Drug interactions
Captopril-hydrochlorothiazide + Levodopa
Severity: Moderate
Captopril-hydrochlorothiazide and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can lower blood pressure and cause orthostatic hypotension. Combined with captopril and hydrochlorothiazide, symptomatic hypotension is more likely, especially at the start of therapy.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Levodopa belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic blood pressure lowering from dopamine-mediated vasodilation and the antihypertensives.
What to do
Monitor standing and sitting blood pressure when starting levodopa or increasing the dose. Reduce the antihypertensive dose if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Levodopa?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can lower blood pressure and cause orthostatic hypotension. Combined with captopril and hydrochlorothiazide, symptomatic hypotension is more likely, especially at the start of therapy.
How serious is the interaction between Captopril-hydrochlorothiazide and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing and sitting blood pressure when starting levodopa or increasing the dose. Reduce the antihypertensive dose if orthostatic symptoms occur.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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