Drug interactions
Captopril-hydrochlorothiazide + Mesalamine
Severity: Minor
Captopril-hydrochlorothiazide and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine can rarely cause nephrotoxicity, and volume depletion from diuretics combined with ACE inhibitor effects on renal hemodynamics may increase vulnerability to kidney injury. A direct pharmacokinetic effect through tubular competition is theoretical.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Theoretical competition for renal tubular secretion, plus additive renal risk from volume depletion and ACE inhibition.
What to do
Monitor serum creatinine at baseline and periodically during mesalamine therapy, and maintain adequate hydration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Mesalamine
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Mesalamine?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mesalamine can rarely cause nephrotoxicity, and volume depletion from diuretics combined with ACE inhibitor effects on renal hemodynamics may increase vulnerability to kidney injury. A direct pharmacokinetic effect through tubular competition is theoretical.
How serious is the interaction between Captopril-hydrochlorothiazide and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine at baseline and periodically during mesalamine therapy, and maintain adequate hydration.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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