Drug interactions
Captopril-hydrochlorothiazide + Methohexital
Severity: Moderate
Captopril-hydrochlorothiazide and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital can cause hypotension during induction of anesthesia. Patients on captopril and hydrochlorothiazide, especially if volume depleted, may have exaggerated drops in blood pressure.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Methohexital belongs to Central Nervous System.
Why it happens
Additive vasodilation and myocardial depression from the anesthetic combined with ACE inhibition and diuretic volume depletion.
What to do
Ensure adequate volume status and monitor blood pressure closely during induction; treat hypotension with fluids or vasopressors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Methohexital
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Methohexital?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital can cause hypotension during induction of anesthesia. Patients on captopril and hydrochlorothiazide, especially if volume depleted, may have exaggerated drops in blood pressure.
How serious is the interaction between Captopril-hydrochlorothiazide and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate volume status and monitor blood pressure closely during induction; treat hypotension with fluids or vasopressors.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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