Drug interactions
Captopril-hydrochlorothiazide + Nadolol
Severity: Minor
Captopril-hydrochlorothiazide and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol adds to the blood pressure lowering of captopril and hydrochlorothiazide and may cause bradycardia or hypotension. Beta-blockers can also slightly raise potassium while thiazides lower it, so the net effect is unpredictable. Thiazides may worsen glucose control.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects with opposing minor effects on potassium.
What to do
Monitor blood pressure, heart rate and serum potassium periodically. Adjust doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Nadolol?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nadolol adds to the blood pressure lowering of captopril and hydrochlorothiazide and may cause bradycardia or hypotension. Beta-blockers can also slightly raise potassium while thiazides lower it, so the net effect is unpredictable. Thiazides may worsen glucose control.
How serious is the interaction between Captopril-hydrochlorothiazide and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium periodically. Adjust doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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