Drug interactions
Captopril-hydrochlorothiazide + Obinutuzumab
Severity: Moderate
Captopril-hydrochlorothiazide and Obinutuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Obinutuzumab infusion reactions may include hypotension, and antihypertensives can worsen this. Labeling advises considering withholding antihypertensives before infusion.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Obinutuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Obinutuzumab belongs to Oncology.
Why it happens
Infusion-related cytokine release and hypotension additive to the vasodilating and diuretic effects of antihypertensives.
What to do
Consider withholding captopril-hydrochlorothiazide for 12 hours before and during the infusion and until 1 hour afterward when clinically appropriate. Monitor blood pressure throughout the infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Obinutuzumab
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Obinutuzumab?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Obinutuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Obinutuzumab infusion reactions may include hypotension, and antihypertensives can worsen this. Labeling advises considering withholding antihypertensives before infusion.
How serious is the interaction between Captopril-hydrochlorothiazide and Obinutuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding captopril-hydrochlorothiazide for 12 hours before and during the infusion and until 1 hour afterward when clinically appropriate. Monitor blood pressure throughout the infusion.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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