Drug interactions
Captopril-hydrochlorothiazide + Oliceridine
Severity: Minor
Captopril-hydrochlorothiazide and Oliceridine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as oliceridine may blunt the diuretic effect of hydrochlorothiazide, and they can also cause hypotension, particularly with volume depletion. The net effect on blood pressure and fluid balance can be unpredictable.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
Why it happens
Opioid-induced antidiuretic hormone release may reduce diuresis, while additive vasodilation and sedation can lower blood pressure.
What to do
Monitor blood pressure, fluid status and urine output when oliceridine is given with this combination. Adjust the diuretic dose if diuresis is diminished.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Oliceridine?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids such as oliceridine may blunt the diuretic effect of hydrochlorothiazide, and they can also cause hypotension, particularly with volume depletion. The net effect on blood pressure and fluid balance can be unpredictable.
How serious is the interaction between Captopril-hydrochlorothiazide and Oliceridine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and urine output when oliceridine is given with this combination. Adjust the diuretic dose if diuresis is diminished.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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