Drug interactions
Captopril-hydrochlorothiazide + Oxaprozin
Severity: Major
Captopril-hydrochlorothiazide and Oxaprozin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of ACE inhibitors and thiazides. In patients taking an ACE inhibitor plus a diuretic, an NSAID adds a risk of acute kidney injury, especially with volume depletion, advanced age or existing renal impairment.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces afferent arteriolar dilation and sodium excretion, opposing ACE inhibitor and diuretic effects and reducing glomerular filtration.
What to do
Avoid regular NSAID use where possible and choose paracetamol or another alternative. If unavoidable, use the lowest dose for the shortest time, ensure hydration, and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Oxaprozin?
MediHelp rates the interaction as major. Captopril-hydrochlorothiazide and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can blunt the blood pressure lowering effect of ACE inhibitors and thiazides. In patients taking an ACE inhibitor plus a diuretic, an NSAID adds a risk of acute kidney injury, especially with volume depletion, advanced age or existing renal impairment.
How serious is the interaction between Captopril-hydrochlorothiazide and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and choose paracetamol or another alternative. If unavoidable, use the lowest dose for the shortest time, ensure hydration, and monitor blood pressure, creatinine and potassium.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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