Drug interactions
Captopril-hydrochlorothiazide + Paclitaxel
Severity: Minor
Captopril-hydrochlorothiazide and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel infusions can cause hypotension and hypersensitivity-type reactions, which may be more noticeable in patients taking antihypertensives such as captopril and hydrochlorothiazide. The interaction is mostly theoretical and is of limited clinical significance.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Paclitaxel belongs to Oncology.
Why it happens
Additive blood pressure lowering from infusion-related hypotension and the antihypertensive combination.
What to do
Monitor blood pressure during infusions and consider holding antihypertensives before chemotherapy if the patient is prone to hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Paclitaxel?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel infusions can cause hypotension and hypersensitivity-type reactions, which may be more noticeable in patients taking antihypertensives such as captopril and hydrochlorothiazide. The interaction is mostly theoretical and is of limited clinical significance.
How serious is the interaction between Captopril-hydrochlorothiazide and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during infusions and consider holding antihypertensives before chemotherapy if the patient is prone to hypotension.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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