Drug interactions
Captopril-hydrochlorothiazide + Piperacillin
Severity: Minor
Captopril-hydrochlorothiazide and Piperacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may modestly reduce the tubular secretion of penicillins and so slightly raise piperacillin concentrations. This is rarely of clinical consequence given the wide therapeutic margin of piperacillin, though volume depletion and renal impairment from the diuretic may also contribute.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Piperacillin belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion via organic anion transporters.
What to do
No routine adjustment is needed. Monitor renal function and electrolytes during prolonged high-dose piperacillin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Acetylsalicylic acid + Piperacillin Moderate
- Amikacin + Piperacillin Moderate
- Antithrombin alfa + Piperacillin Moderate
- Antithrombin iii + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Piperacillin?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may modestly reduce the tubular secretion of penicillins and so slightly raise piperacillin concentrations. This is rarely of clinical consequence given the wide therapeutic margin of piperacillin, though volume depletion and renal impairment from the diuretic may also contribute.
How serious is the interaction between Captopril-hydrochlorothiazide and Piperacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and electrolytes during prolonged high-dose piperacillin therapy.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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