Drug interactions
Captopril-hydrochlorothiazide + Prednisone
Severity: Moderate
Captopril-hydrochlorothiazide and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazides and corticosteroids promote potassium loss. Together they may cause hypokalemia, and corticosteroids can also cause fluid retention and raise blood pressure, opposing the antihypertensive effect.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide action and the mineralocorticoid effect of prednisone, plus sodium and fluid retention.
What to do
Monitor serum potassium and blood pressure, particularly with prolonged or high-dose steroid therapy. Supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Prednisone?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazides and corticosteroids promote potassium loss. Together they may cause hypokalemia, and corticosteroids can also cause fluid retention and raise blood pressure, opposing the antihypertensive effect.
How serious is the interaction between Captopril-hydrochlorothiazide and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, particularly with prolonged or high-dose steroid therapy. Supplement potassium if needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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