Drug interactions
Captopril-hydrochlorothiazide + Probenecid
Severity: Moderate
Captopril-hydrochlorothiazide and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides raise serum uric acid and can reduce the uricosuric effect of probenecid. Hydrochlorothiazide may also compete for renal tubular secretion, and probenecid can raise hydrochlorothiazide and captopril levels.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Competition for renal organic anion transport and thiazide-induced hyperuricemia opposing uricosuric action.
What to do
Monitor serum uric acid and gout control, adjusting probenecid dose if needed. Watch for hypotension or enhanced diuretic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Probenecid?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides raise serum uric acid and can reduce the uricosuric effect of probenecid. Hydrochlorothiazide may also compete for renal tubular secretion, and probenecid can raise hydrochlorothiazide and captopril levels.
How serious is the interaction between Captopril-hydrochlorothiazide and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control, adjusting probenecid dose if needed. Watch for hypotension or enhanced diuretic effects.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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