Drug interactions
Captopril-hydrochlorothiazide + Riociguat
Severity: Moderate
Captopril-hydrochlorothiazide and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riociguat lowers blood pressure and may cause symptomatic hypotension when combined with captopril and hydrochlorothiazide. Risk is greater in volume-depleted patients and after dose increases.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Additive vasodilation through soluble guanylate cyclase stimulation, ACE inhibition and diuretic effects.
What to do
Monitor blood pressure and consider reducing the antihypertensive dose if symptomatic hypotension occurs. Titrate riociguat per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Riociguat?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riociguat lowers blood pressure and may cause symptomatic hypotension when combined with captopril and hydrochlorothiazide. Risk is greater in volume-depleted patients and after dose increases.
How serious is the interaction between Captopril-hydrochlorothiazide and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and consider reducing the antihypertensive dose if symptomatic hypotension occurs. Titrate riociguat per labeling.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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