Drug interactions
Captopril-hydrochlorothiazide + Secobarbital
Severity: Moderate
Captopril-hydrochlorothiazide and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital can lower blood pressure through CNS depression and vasodilation, adding to the effect of captopril and hydrochlorothiazide. Orthostatic hypotension and falls are possible.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects.
What to do
Monitor blood pressure and warn the patient about dizziness when standing. Adjust antihypertensive dosing if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Secobarbital?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital can lower blood pressure through CNS depression and vasodilation, adding to the effect of captopril and hydrochlorothiazide. Orthostatic hypotension and falls are possible.
How serious is the interaction between Captopril-hydrochlorothiazide and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and warn the patient about dizziness when standing. Adjust antihypertensive dosing if hypotension develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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