Drug interactions
Captopril-hydrochlorothiazide + Sufentanil
Severity: Moderate
Captopril-hydrochlorothiazide and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil can cause hypotension and bradycardia, which may add to the blood-pressure lowering of captopril and hydrochlorothiazide. Hypotension is most likely during anesthesia or in volume-depleted patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects through opioid-induced vasodilation and reduced sympathetic tone combined with ACE inhibition and diuresis.
What to do
Monitor blood pressure closely during perioperative or analgesic use of sufentanil. Correct volume depletion and consider holding antihypertensives before surgery according to local protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Sufentanil?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil can cause hypotension and bradycardia, which may add to the blood-pressure lowering of captopril and hydrochlorothiazide. Hypotension is most likely during anesthesia or in volume-depleted patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during perioperative or analgesic use of sufentanil. Correct volume depletion and consider holding antihypertensives before surgery according to local protocol.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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