Drug interactions
Captopril-hydrochlorothiazide + Tolbutamide
Severity: Moderate
Captopril-hydrochlorothiazide and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and increase the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. Thiazides may work in the opposite direction by raising glucose.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
Enhanced insulin sensitivity from ACE inhibition adds to sulfonylurea insulin secretion; thiazide may partly raise glucose.
What to do
Monitor blood glucose when starting or changing captopril and counsel on hypoglycemia symptoms. Reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Tolbutamide?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and increase the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. Thiazides may work in the opposite direction by raising glucose.
How serious is the interaction between Captopril-hydrochlorothiazide and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing captopril and counsel on hypoglycemia symptoms. Reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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