Drug interactions
Captopril-hydrochlorothiazide + Vardenafil
Severity: Moderate
Captopril-hydrochlorothiazide and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil is a vasodilator and can lower blood pressure, which may add to the effects of an ACE inhibitor and thiazide. Symptomatic hypotension is possible, especially in volume-depleted or older patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
Why it happens
Additive vasodilation through PDE5 inhibition and antihypertensive effects.
What to do
Start vardenafil at the lowest dose and monitor blood pressure and symptoms. Advise patients to rise slowly and report dizziness or fainting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Vardenafil?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vardenafil is a vasodilator and can lower blood pressure, which may add to the effects of an ACE inhibitor and thiazide. Symptomatic hypotension is possible, especially in volume-depleted or older patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start vardenafil at the lowest dose and monitor blood pressure and symptoms. Advise patients to rise slowly and report dizziness or fainting.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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