Drug interactions
Captopril-hydrochlorothiazide + Voclosporin
Severity: Major
Captopril-hydrochlorothiazide and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause hyperkalemia, reduced glomerular filtration and hypertension. With an ACE inhibitor, the risk of hyperkalemia and acute renal function decline is increased, although thiazide may offset potassium partly.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibitor-induced afferent vasoconstriction and reduced potassium excretion add to ACE inhibitor effects on efferent tone and aldosterone.
What to do
Monitor serum potassium and eGFR regularly, as recommended in voclosporin labeling, and reduce the voclosporin dose or review the ACE inhibitor if hyperkalemia or eGFR decline occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Voclosporin?
MediHelp rates the interaction as major. Captopril-hydrochlorothiazide and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin, a calcineurin inhibitor, can cause hyperkalemia, reduced glomerular filtration and hypertension. With an ACE inhibitor, the risk of hyperkalemia and acute renal function decline is increased, although thiazide may offset potassium partly.
How serious is the interaction between Captopril-hydrochlorothiazide and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and eGFR regularly, as recommended in voclosporin labeling, and reduce the voclosporin dose or review the ACE inhibitor if hyperkalemia or eGFR decline occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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