Drug interactions
Carbachol + Desipramine
Severity: Minor
Carbachol and Desipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a cholinergic agonist, and desipramine's antimuscarinic activity may partly oppose its effects. The clinical effect is unclear, and systemic exposure from ophthalmic use is minimal.
What this interaction means in plain words
Carbachol and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbachol belongs to Miscellaneous; Desipramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition between cholinergic agonism and antimuscarinic activity of desipramine.
What to do
No specific action is needed. Be aware that the cholinergic effect of carbachol may be reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Desipramine?
MediHelp rates the interaction as minor. Carbachol and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbachol is a cholinergic agonist, and desipramine's antimuscarinic activity may partly oppose its effects. The clinical effect is unclear, and systemic exposure from ophthalmic use is minimal.
How serious is the interaction between Carbachol and Desipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Be aware that the cholinergic effect of carbachol may be reduced.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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